Lucie Carrier, PhD, is Professor of “Functional Genomics of Cardiomyopathies” and team leader in the Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center at the University Medical Center Hamburg-Eppendorf, Germany. She is best known for her work on genetics and pathophysiology of hypertrophic cardiomyopathy (HCM), including elucidation of the pathomechanisms of mutations in MYBPC3, encoding cardiac myosin-binding protein C, and contribution of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Her recent interest is the development of HCM modeling with human iPSC and CRISPR/Cas9 gene technology and engineered heart tissues, and MYBPC3 gene therapy (by exon skipping, trans-splicing, gene replacement and CRISPR/Cas9) in iPSC-derived cardiomyocytes and engineered heart tissues, mouse and large animal models for severe forms of pediatric cardiomyopathy.
